Frequently Asked Questions

How is REVOLUTION PLUS different from REVOLUTION®?

REVOLUTION PLUS builds upon the proven 5-in-1 protection of REVOLUTION®, veterinarians’ #1 trusted pest treatment for cats—PLUS it now protects against ticks, too.1,20

With one monthly dose, REVOLUTION PLUS broadens the scope of pest protection to 6 common parasites that are harmful for both indoor and outdoor cats and kittens, with unique dual action against fleas and ear mites.

5-in-1 Parasite Protection 5-in-1 Parasite Protection
6-in-1 Parasite Protection 6-in-1 Parasite Protection


What parasites does REVOLUTION PLUS protect against in cats and kittens?

REVOLUTION PLUS broadens the scope of protection for cats and kittens, inside and out, against fleas, ticks, ear mites, roundworms, hookworms, and heartworms. Get the 6-in-1 Protection Basics

My cat only lives indoors. Is parasite protection necessary?

Parasites are not outdoor-only. Fleas, ticks, ear mites, intestinal worms, and heartworms can get into any home. Parasites hitchhike indoors on other pets or creatures, on shoes and clothes, or get inside through doors and windows. Cats and kittens of all lifestyles (indoor-only, indoor/outdoor, outdoor-only) can regularly come in contact with parasites and their health risks. With one monthly dose, REVOLUTION PLUS provides broad-spectrum coverage against common pests that both indoor and outdoor cats need.

How do I apply REVOLUTION PLUS to my cat?

REVOLUTION PLUS is a simple-to-apply, quick-drying, small-volume, monthly topical solution—so there’s no need to hassle with larger volume topicals or giving your cat a pill! Check out our illustrated how-to guide.

See How

What are the side effects of REVOLUTION PLUS for cats?

The most commonly reported side effects in clinical trials were temporary loss of appetite and drowsiness. No side effects were noted when REVOLUTION PLUS was used along with commonly prescribed veterinary products.

While there was a low incidence of side effects in clinical trials, it’s important to report to your veterinarian any unusual signs or activity in your cat or kitten after applying the product.

Is REVOLUTION PLUS safe for cats and kittens?

REVOLUTION PLUS is proven safe for cats and kittens as young as 8 weeks of age, weighing 2.8 lbs or greater. The safe use of REVOLUTION PLUS has not been established in kittens less than 8 weeks old or breeding, pregnant, or lactating cats.

Since one of the active ingredients (sarolaner) in REVOLUTION PLUS is a member of the isoxazoline class, use with caution in cats with a history of neurologic disorders such as seizures. REVOLUTION PLUS has been administered in conjunction with numerous cat medications and may be given to cats with adult heartworm infection.

How can I decide which pest protection is best for my cat?

It’s always best to talk with your veterinarian about the right protection for your furry friend. But a good start is looking at our comparison chart to see how the REVOLUTION PLUS label compares to that of other pest preventatives. Only REVOLUTION PLUS provides broad-spectrum, 6-in-1 protection against fleas, ticks (black-legged or deer tick, Gulf Coast tick, and American dog tick), ear mites, roundworms, hookworms and heartworms, with unique dual action against fleas and ear mites.

Are ticks common in cats?

Though certain ticks are more prominent in certain areas (i.e., Gulf Coast tick in Southeastern and mid-Atlantic states; American dog tick east of the Rocky Mountains and Pacific coast; black-legged or deer tick across eastern U.S.), cat owners should be vigilant with year-round tick and other pest protection in all 50 states to ensure cats of all lifestyles (indoor-only, indoor/outdoor, outdoor-only) are properly protected with broad-spectrum preventative medicine such as REVOLUTION PLUS.

Where is REVOLUTION PLUS manufactured?

Zoetis manufactures REVOLUTION PLUS in Kalamazoo, Michigan.

Where can I get REVOLUTION PLUS?

REVOLUTION PLUS is a prescription medication available from your veterinarian. Please contact your veterinarian to discuss REVOLUTION PLUS for your cat or kitten.